Way to exclude segments on mailing lists?

I'm trying to exclude one segment of our audience from an email campaign.

We sent campaign one to a subgroup that includes some folks from our main list. 

Now we want to send a different email to the main list but exclude that subgroup.

Is this possible with sqsp?

Thank you!

Did you figure this out? I'm also struggling with excluding certain customer groups when sending emails.

Also interested - Has this been answered?

I wonder if we would ever get segmentation or list organization ...like flodesk does? i would jump ship and come back to email campaign if we have workflows and segmentation.